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MODAG - Neuroscience Solutions

Publications

 

About "anle 138b"

• Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease.
Publication published on PubMed Central.

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• The oligomer modulator anle138b inhibits disease progression in a Parkinson mouse model even with treatment started after disease onset.
Publication published on PubMed Central.

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• Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies.
Publication published on PubMed Central.

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• Resolving the Atomistic Modes of Anle138b Inhibitory Action on Peptide Oligomer Formation.
Publication published on PubMed Central.

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• The diphenylpyrazole compound anle138b blocks Ab channels and rescues disease phenotypes in a mouse model for amyloid pathology.
Publication published on PubMed Central.

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• Anle138b Modulates α-Synuclein Oligomerization and Prevents Motor Decline and Neurodegeneration in a Mouse Model of Multiple System Atrophy.
Publication published on Wiley Online Library.

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• Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson's disease model.
Publication published on PubMed Central.

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About "qRT-QuIC"

• Establishing quantitative real-time quaking-induced conversion (qRT-QuIC) for highly sensitive detection and quantification of PrPSc in prion-infected tissues.
Publication published on PubMed Central.

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• Quantitative Real-Time Quaking-Induced Conversion Allows Monitoring of Disease-Modifying Therapy in the Urine of Prion-Infected Mice.
Publication published on PubMed Central.

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